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ajidahk - I take the Spring Valley Super B complex (Walmart's brand). You're supposed to take one daily but I split it in half and take it with my MSM. I take 2000mcgs of MSM twice daily (total of 4000mcgs), vitamin C (or orange juice) and a multi-vitamin. It seems to work better for me splitting ALL my pills in half so that I can make sure they're working along with my MSM dosages.
And to answer your question, there is only about 3.8mcgs of Biotin in my Super B complex so that's not much. Most people say that B vitamins work better when they're balanced out. When I took 1000-2000mcgs of Biotin I had horrible breakouts so I had to stop taking them. But everybody's different and not everybody breaks out. I may sneak Biotin back in gradually at some point since I'm taking the super B complex but I'm still afraid. The Biotin did seem to have me growing hair everywhere.
You say you take 400mcgs of MSM, right?? And 2000mcgs of Biotin? Did you begin taking them both at the same time or did you start one before the other? I ask because you seem to be sure that it's the MSM breaking you out and not the Biotin. My first guess would be the Biotin since the MSM is a very small dosage that you're taking and Biotin is known to cause breakouts even more.
Whichever you're taking make sure you start out slowly taking them and keep a journal so you know what you started and when symptoms started. Plus, you'll get to learn if your cystic acne is hormonal or not. The MSM aggravates my hormones, which can cause cystic acne. The Biotin gave me pimples/bumps almost as soon as I would take them and almost every day of the month. So that's a way to tell the difference. I can deal with hormonal stuff but not one pimple after another every day.
HTH!!