Yes, I deep condition while I have braids in. Actually, I do to my braids whatever I'd do to my hair if it was out of braids. I just make sure I rinse well both after shampooing and conditioning; and I always do a final rinse with an apple cider vinegar solution. Some people dilute the conditioner before applying it to their braids. I don't, but it's really up to you. I will also mention that even though I wear braids 24/7, I spot-touch them regularly so my hair doesn't somewhat mat as would happen if you had build-up on braids and kept them in too long. (ACV rinses help with removing build-up and making your hair cuticle lie flat so it tangles less, BTW.)