I used Motions my last touch up. Before that I was using Optimum Care lye and no lye. I basically switched back and forth depending on how much money I had at the time. I think as long as you don't overlap, overprocess, or under neutralize, you should be fine. I have not had any adverse reactions and I am currently 2 weeks post relaxer. I used Motions Oil moisturizer relaxer mild. And I believe that I timed it for 20 mins for application and smoothing. I did not burn, but it was strange, using a silk protein conditioner before shampooing with neutralizer. It did make my hair feel nice though. I am not using it as part of my regular regime though. But I did have very good results.